Abstract
This mini-review provides a comprehensive analysis of the global resurgence of mpox, highlighting its significant impact as a zoonotic disease since the World Health Organization declared it a Public Health Emergency of International Concern in July 2022. As of mid-June 2024, approximately 98,000 cases and 200 deaths have been reported across 116 countries. The review details the transmission dynamics, regional impacts, and the disease's prevalence among high-risk groups, particularly men who have sex with men (MSM). It discusses the effectiveness of current containment strategies, including vaccination, surveillance, and public health interventions. The review emphasizes the need for targeted health policies, robust international cooperation, and sustained preventive measures to mitigate the ongoing global impact of mpox.Keywords:
Monkeypox, Mpox Clade, hMPXV, men who have sex with men (MSM), LGBTQ, Poxviridae, small pox, Global Trends, Clade IIa, DR CongoReferences
Sarker R, Roknuzzaman ASM, Shahriar M, Bhuiyan MA, Islam MR. The WHO has ended public health emergency of international concern for mpox: assessment of upside and downside of this decision. Int J Surg. 2023;109(10):3238-9.
Iñigo Martínez J, Gil Montalbán E, Jiménez Bueno S, Martín Martínez F, Nieto Juliá A, Sánchez Díaz J, et al. Monkeypox outbreak predominantly affecting men who have sex with men, Madrid, Spain, 26 April to 16 June 2022. Euro Surveill. 2022;27(27).
Ahmed SK, Mohamed MG, Dabou EA, Abuijlan I, Chandran D, El-Shall NA, et al. Monkeypox (mpox) in immunosuppressed patients. F1000Res. 2023;12:127.
World Health Organization. 2022-24 Mpox (Monkeypox) Outbreak: Global Trends [ Internet]. [cited 2024 Jun 28]; Available from: https://worldhealthorg.shinyapps.io/mpx_global/#4_Africa_in_Focus
Van Dijck C, Hoff NA, Mbala-Kingebeni P, Low N, Cevik M, Rimoin AW, et al. Emergence of mpox in the post-smallpox era 2014;a narrative review on mpox epidemiology. Clin Microbiol Infect. 2023;29(12):1487-92.
2022-2023 Mpox Outbreak Global Map [Internet]. [cited 2024 jun 28]; Available from: https://www.cdc.gov/poxvirus/mpox/response/2022/world-map.html
Ghosh D. New Mpox Strain In DR Congo 'Most Dangerous Yet' , Warns WHO And Scientists Debosmita Ghosh [Internet]. [cited 2024 jun 28]; Available from: https://www.timesnownews.com/health/new-mpox-strain-in-dr-congo-most-dangerous-yet-warns-who-and-scientists-article-111299791
Costa AF, Rocha SQ, Fonsi M, Nogueira RS, Kalichman AO, Madruga JVR, et al. Clinical and epidemiological features of mpox in a Brazilian reference center for HIV and sexually transmitted infections: A cross-sectional study. IJID Regions. 2024;10:114-22.
Chakraborty C, Bhattacharya M, Pandya P, Dhama K. Monkeypox in South-East Asia: Is an alarming bell for this region? - Correspondence. Int J Surg. 2022;106:106917.
Zong Y, Yang Y, Kong D, Xu J, Liang Z, Shi F, et al. Epidemiology and characteristics of identified early mpox cases in Guangdong Province, China: Implications for prevention and control. Biosafety and Health. 2023;5(6):321-5.
Ianache I, Skrzat-Klapaczynska A, Jilich D, Fleischhans L, Gmizic I, Ranin J, et al. Mpox across countries from Central and Eastern Europe - 2022 outbreak. Travel Med Infect Dis. 2024;59:102719.
World Health Organization. 2022-24 Mpox (Monkeypox) Outbreak: Global Trends [Internet].[cited 2024 jun 28]; Available from: https://worldhealthorg.shinyapps.io/mpx_global/#4_Africa_in_Focus
CDC. 2022-2023 US Map & Case Count: CDC [Internet]. [cited 2024 jun 28]; Available from: https://www.cdc.gov/poxvirus/mpox/response/2022/us-map.html
Laurenson-Schafer H, Sklenovská N, Hoxha A, Kerr SM, Ndumbi P, Fitzner J, et al. Description of the first global outbreak of mpox: an analysis of global surveillance data. Lancet Glob Health. 2023;11(7):e1012-e23.
Zhao T, Wu Z. Prevention of a potential mpox outbreak in China. The Lancet. 2023;402(10407):1038-9.
Kibungu EM, Vakaniaki EH, Kinganda-Lusamaki E, Kalonji-Mukendi T, Pukuta E, Hoff NA, et al. Clade I-Associated Mpox Cases Associated with Sexual Contact, the Democratic Republic of the Congo. Emerg Infect Dis. 2024;30(1):172-6.
Mitjà O, Ogoina D, Titanji BK, Galvan C, Muyembe JJ, Marks M, Orkin CM. Monkeypox. Lancet. 2023;401(10370):60-74.
Vogel L. Making sense of monkeypox death rates. CMAJ. 2022;194(31):E1097.
Beeson A, Styczynski A, Hutson CL, Whitehill F, Angelo KM, Minhaj FS, et al. Mpox respiratory transmission: the state of the evidence. The Lancet Microbe. 2023;4(4):e277-e83.
Walter C. Mpox: what to watch out for, treatment and what to worry about [Internet]. [cited 2024 jun 28]; Available from: https://theconversation.com/mpox-what-to-watch-out-for-treatment-and-what-to-worry-about-233466
Acharya A, Kumar N, Singh K, Byrareddy SN. "Mpox in MSM: Tackling Stigma, Minimizing Risk Factors, Exploring Pathogenesis, and Treatment Approaches". Biomedical Journal. 2024:100746.
Guzzetta G, Marziano V, Mammone A, Siddu A, Ferraro F, Caraglia A, et al. The decline of the 2022 Italian mpox epidemic: Role of behavior changes and control strategies. Nat Commun. 2024;15(1):2283.
Silva S, Kohl A, Pena L, Pardee K. Clinical and laboratory diagnosis of monkeypox (mpox): Current status and future directions. iScience. 2023;26(6):106759.
Berry MT, Khan SR, Schlub TE, Notaras A, Kunasekaran M, Grulich AE, et al. Predicting vaccine effectiveness for mpox. Nat Commun. 2024;15(1):3856.
Lu J, Xing H, Wang C, Tang M, Wu C, Ye F, et al. Mpox (formerly monkeypox): pathogenesis, prevention, and treatment. Signal Transduct Target Ther. 2023;8(1):458.
Tajudeen YA, Oladipo HJ, Muili AO, Ikebuaso JG. Monkeypox: A review of a zoonotic disease of global public health concern. Health Promot Perspect. 2023;13(1):1-9.
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Copyright (c) 2024 Saloni Saloni, Srilatha Marate, Biju Soman, Arabindo Tanti, Azra khan, Amit Kumar Goyal, Pawan Kumar
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