Abstract

Microneedle technology has emerged as a significant advancement in medical science, revolutionizing approaches to vaccine delivery, chronic disease management, and dermatological treatments. Its minimal invasiveness, ease of use, and potential to enhance healthcare access are particularly beneficial in resource-limited settings. The application of this technology spans various domains such as simplifying vaccination processes, facilitating non-invasive chronic disease monitoring, and improving the delivery of dermatological treatments. Recent studies have demonstrated the potential to increase vaccination rates, provide pain-free chronic disease management, and offer efficient drug delivery systems in dermatology and cancer treatments. However, certain challenges remain, including overcoming social stigma, regulatory hurdles, and manufacturing issues. Continued research and collaboration are essential to overcome these barriers and realizing the full potential of microneedle technology in transforming healthcare.

Keywords:

microneedle technology, vaccine delivery, chronic disease management, non-invasive monitoring, drug delivery systems

References

Bao Z, Lu S, Zhang D, Wang G, Cui X, Liu G. Wearable Microneedle Patch for Colorimetric Detection of Multiple Signature Biomarkers in vivo Toward Diabetic Diagnosis. Adv Healthc Mater. 2024:e2303511.

Umesh DJ, Dhanashree UJ, Sohel MS, Yuvraj PS, Shreya SK, Shweta SH, et al. Microneedles : A Smart Approach for Transdermal Drug Delivery System. International Journal of Scientific Research in Science and Technology. 2023:612-23.

Zhao ZQ, Liang L, Jing LY, Liu Y, Zhang YH, Shahbazi M-A, et al. Microneedles: a novel strategy for wound management. Biomaterials Science. 2023;11(13):4430-51.

Feng Y-X, Hu H, Wong Y-Y, Yao X, He M-L. Microneedles: An Emerging Vaccine Delivery Tool and a Prospective Solution to the Challenges of SARS-CoV-2 Mass Vaccination. Pharmaceutics. 2023;15(5):1349.

Dugad B, Bhattacharya S. The Microneedle Drug Delivery System and some Recent Obstacles in its Implementation. Nanoscience & Nanotechnology-Asia. 2023;13(4):28-46.

Laskar TT, Arora M. Microneedles: Recent advances and development in the field of transdermal drug delivery technology. Journal of Drug Delivery and Therapeutics. 2023;13(3):155-63.

Ganeson K, Alias AH, Murugaiyah V, Amirul A-AA, Ramakrishna S, Vigneswari S. Microneedles for Efficient and Precise Drug Delivery in Cancer Therapy. Pharmaceutics. 2023;15(3):744.

De Decker I, Logé T, Hoeksema H, Speeckaert MM, Blondeel P, Monstrey S, et al. Dissolving microneedles for effective and painless intradermal drug delivery in various skin conditions: A systematic review. The Journal of Dermatology. 2023;50(4):422-44.

Nguyen HX, Nguyen CN. Microneedle-Mediated Transdermal Delivery of Biopharmaceuticals. Pharmaceutics. 2023;15(1):277.

Luo X, Yang L, Cui Y. Microneedles: materials, fabrication, and biomedical applications. Biomedical Microdevices. 2023;25(3):20.

Münch S, Wohlrab J, Neubert RHH. Dermal and transdermal delivery of pharmaceutically relevant macromolecules. European Journal of Pharmaceutics and Biopharmaceutics. 2017;119:235-42.

Lee W-R, Shen S-C, Al-Suwayeh SA, Yang H-H, Li Y-C, Fang J-Y. Skin Permeation of Small-Molecule Drugs, Macromolecules, and Nanoparticles Mediated by a Fractional Carbon Dioxide Laser: The Role of Hair Follicles. Pharmaceutical Research. 2012;30(3):792-802.

Becker S, Zorec B, Miklavčič D, Pavšelj N. Transdermal transport pathway creation: Electroporation pulse order. Mathematical Biosciences. 2014;257:60-8.

Masterson J, Kluge B, Burdette A, Sr GL. Sustained Acoustic medicine; Sonophoresis for Nonsteroidal anti-inflammatory Drug Delivery in Arthritis. Therapeutic Delivery. 2020;11(6):363-72.

Karande P, Jain A, Mitragotri S. Discovery of transdermal penetration enhancers by high-throughput screening. Nature Biotechnology. 2004;22(2):192-7.

Rawat S, Vengurlekar S, Rakesh B, Jain S, Srikarti G. Transdermal delivery by iontophoresis. Indian Journal of Pharmaceutical Sciences. 2008;70(1):5.

Vaseem RS, D’cruz A, Shetty S, Hafsa, Vardhan A, R SS, et al. Transdermal Drug Delivery Systems: A Focused Review of the Physical Methods of Permeation Enhancement. Advanced Pharmaceutical Bulletin. 2024;14(1):67.

Ruan S, Li J, Ruan H, Xia Q, Hou X, Wang Z, et al. Microneedle-mediated nose-to-brain drug delivery for improved Alzheimer's disease treatment. Journal of Controlled Release. 2024;366:712-31.

Lin H, Liu J, Hou Y, Yu Z, Hong J, Yu J, et al. Microneedle patch with pure drug tips for delivery of liraglutide: pharmacokinetics in rats and minipigs. Drug Delivery and Translational Research. 2024:1-5.

Yang F, Wang W, Zhou J, Yu Z, An M, He W, et al. Transdermal delivery of IBU-PLGA nanoparticles with dissolving microneedle array patch. Journal of Drug Delivery Science and Technology. 2024; 95:105528.

Adigweme I, Yisa M, Ooko M, Akpalu E, Bruce A, Donkor S, et al. A measles and rubella vaccine microneedle patch in The Gambia: a phase 1/2, double-blind, double-dummy, randomised, active-controlled, age de-escalation trial. The Lancet. 2024;403(10439):1879-92.

Zhao C, Wu Z, Pan B, Zhang R, Golestani A, Feng Z, et al. Functional biomacromolecules-based microneedle patch for the treatment of diabetic wound. Int J Biol Macromol. 2024;267(Pt 2):131650.

Lyu S, Liu Q, Yuen HY, Xie H, Yang Y, Yeung KW, et al. A differential-targeting core-shell microneedle patch with coordinated and prolonged release of mangiferin and MSC-derived exosomes for scarless skin regeneration. Mater Horiz. 2024;11(11):2667-84.

Nogueira AS, Garcia MAC, Silva MBD, Costa PFD, Frade MAC, Salgado CG, et al. Clofazimine-induced cutaneous hyperpigmentation as a source of stigma in the treatment of leprosy: A cross-sectional study. Trop Med Int Health. 2024;29(4):327-33.

Azizi Machekposhti S, Khanna S, Shukla S, Narayan R. Microneedle fabrication methods and applications. MRS Communications. 2023;13(2):212-24.

Malek-Khatabi A, Sadat Razavi M, Abdollahi A, Rahimzadeghan M, Moammeri F, Sheikhi M, et al. Recent progress in PLGA-based microneedle-mediated transdermal drug and vaccine delivery. Biomaterials Science. 2023;11(16):5390-409.

How to Cite

Bajwa, N., Devulapalli, V., Mahendra Pratap Singh, Gopi, K., Shariff, S., Kumar, P., & Quispe-Vicuña, C. (2024). Microneedle technology: a gateway to transformative healthcare solutions. The Evidence, 2(3). https://doi.org/10.61505/evidence.2024.2.3.57

Most read articles by the same author(s)

Loading...