Abstract
Background
There is increasing evidence that magnesium sulfate (MgSO4) is widely recognized as the preferred medicine for preventing and treating pre-eclampsia/eclampsia. Several investigations have shown that one of the obstacles to the successful use of MgSO4 is the limited understanding of midwives about its administration. This study aims to assess midwives’ knowledge and practice of magnesium sulfate administration to pre-eclamptic pregnant women in the Tamale West Hospital.
Methods
A total of 114 midwives were selected for the research using a process of simple random selection. The research used observational descriptive study with cross sectional study design. The data was analyzed using descriptive statistics via the use of SPSS version 26. Chi-square test was used to compare categorical variables, and a p-value less than 0.05 was deemed statistically significant.
Results
A total of 114 respondents were recruited in this study. The minimum and maximum ages were 21 and 41 years, respectively. All midwives have heard about MgSO4. The majority of respondents (43.9%) have heard about magnesium sulfate from tutors/lecturers, 24.6% from other sources, 17.5% from the media (TV, Radio& Internet), and 14% from colleagues. More than half of the respondents (53.5%) had good knowledge of respondents on MgSO4 administration. The majority of the respondents (64.9%) have administered magnesium sulfate. The specific role of the midwives in preventing MgSO4 toxicity includes Calling a colleague (24.3%), giving an antidote (45.9%), regular BP monitoring (52.7%), and urine output and protein (55.4%). Also, 71.1% of the respondents prefer other medications for managing eclampsia. The research found a strong statistical correlation between the administration of MgSo4 and age (p=0.031), years of experience (p=0.001), and workplace (p=0.009).
Conclusion
Most of the responders had understanding of magnesium sulfate dosage. Additionally, some midwives reported to have administered MgSO4 to their patients in the past. The research found a substantial statistical correlation between the administration of MgSo4 and factors such as age, years of experience, and workplace.
Keywords:
Knowledge, practices, midwives, magnesium sulfate, pre-eclampsia, eclampsia, administrationReferences
References
Bartal MF, Sibai BM. Eclampsia in the 21st century. Am J Obstet Gynecol 2022; 226: S1237–S1253.
Facca TA, Famá EAB, Mastroianni-Kirsztajn G, et al. Why Is Preeclampsia Still an Important Cause of Maternal Mortality Worldwide? Rev Bras Ginecol e Obs 2020; 42: 586–587.
Stitterich N, Shepherd J, Koroma MM, et al. Risk factors for preeclampsia and eclampsia at a main referral maternity hospital in Freetown, Sierra Leone: a case-control study. BMC Pregnancy Childbirth 2021; 21: 413.
Njukang NE, Thomas Obinchemti E, Sama M, et al. Prevalence and risk factors of hypertensive disorders in pregnancy: the case of mezam division, NWR Cameroon. J Womens Heal Dev 2020; 3: 247–267.
Adepoju AA, Vidler M, Akadri AA, et al. The ability and safety of community-based health workers to safely initiate lifesaving therapies for pre-eclampsia in Ogun State, Nigeria: An analysis of 260 community treatments with MgSO4 and/or methyldopa. Pregnancy Hypertens 2021; 25: 179–184.
Aukes AM, Arion K, Bone JN, et al. Causes and circumstances of maternal death: a secondary analysis of the Community-Level Interventions for Pre-eclampsia (CLIP) trials cohort. Lancet Glob Heal 2021; 9: e1242–e1251.
Eddy KE, Vogel JP, Zahroh RI, et al. Factors affecting use of magnesium sulphate for pre‐eclampsia or eclampsia: a qualitative evidence synthesis. BJOG An Int J Obstet Gynaecol. 2022; 129: 379–391.
Dehaene I, Van Steenstraeten T, De Coen K, et al. Correction to: Neonatal magnesium levels are safe after maternal MgSO4 administration: a comparison between unexposed preterm neonates and neonates exposed for fetal neuroprotection or maternal eclampsia prevention-a cohort study. Eur J Pediatr. 2022;181(8):2971-80.
Hossain, Sharif M.I., Shongkour Roy, Kanij Sultana, and Charlotte E. Warren. 2019. "Assessing the effect of a primary health care intervention for improving pre-eclampsia and eclampsia knowledge and practice in Bangladesh," Ending Eclampsia Endline Report. Washington, DC: Population Council.
Padda J, Khalid K, Colaco LB, et al. Efficacy of magnesium sulfate on maternal mortality in eclampsia. Cureus; 13.
World Health Organization. WHO recommendations for prevention and treatment of pre-eclampsia and eclampsia: summary of recommendations. World Health Organization, 2011.
Ulviana U, Novita N. Effectiveness of MGSO4 Administration Against Prevention of Eclampsia in Severe Pre-Eclampsia in RSIA Resti Mulya in 2022. J Keperawatan Komprehensif (Comprehensive Nurs Journal); 8(Special Edition).
Gordon R, Magee LA, Payne B, et al. Magnesium sulphate for the management of preeclampsia and eclampsia in low and middle income countries: a systematic review of tested dosing regimens. J Obstet Gynaecol Canada 2014; 36: 154–163.
Kim YM, Ansari N, Kols A, et al. Prevention and management of severe pre-eclampsia/eclampsia in Afghanistan. BMC Pregnancy Childbirth 2013; 13: 1–10.
Duley L, Gülmezoglu AM, Henderson‐Smart DJ,Chou D. Magnesium sulphate and other anticonvulsants for women with pre‐eclampsia. Cochrane database Syst Rev. 2010(11).
Chappell LC, Cluver CA, Tong S. Pre-eclampsia. Lancet 2021; 398: 341–354.
Arechvo A, Voicu D, Gil MM, et al. Maternal race and pre‐eclampsia: Cohort study and systematic review with meta‐analysis. BJOG An Int J Obstet Gynaecol 2022; 129: 2082–2093.
Tesfa E, Nibret E, Munshea A. Maternal lipid profile and risk of pre-eclampsia in African pregnant women: A systematic review and meta-analysis. PLoS One 2020; 15: e0243538.
Toloza FJ, Derakhshan A, Männistö T, et al. Association between maternal thyroid function and risk of gestational hypertension and pre-eclampsia: a systematic review and individual-participant data meta-analysis. Lancet Diabetes Endocrinol. 2022;10(4):243-52.
Khatri RB, Dangi TP, Gautam R, et al. Barriers to utilization of childbirth services of a rural birthing center in Nepal: A qualitative study. PLoS One 2017; 12: 1–20.
Hughes AJ, Fraser DM. ‘SINK or SWIM’: the experience of newly qualified midwives in England. Midwifery 2011; 27: 382–386.
Bergman L, Torres-Vergara P, Penny J, et al. Investigating maternal brain alterations in preeclampsia: the need for a multidisciplinary effort. Curr Hypertens Rep 2019; 21: 1–13.
Bigdeli M, Zafar S, Assad H, et al. Health system barriers to access and use of magnesium sulfate for women with severe pre-eclampsia and eclampsia in Pakistan: evidence for policy and practice. PLoS One 2013; 8: e59158.
Adefemi SA, Adeleke IT, Gara P, et al. The rate, reasons and predictors of hospital discharge against medical advice among inpatients of a tertiary health facility in North-central Nigeria. Am J Heal Res 2015; 3: 11–16.
Polit DF, Beck CT. Nursing research: Generating and assessing evidence for nursing practice. Lippincott Williams & Wilkins, 2008.
Yamane T. Elementary sampling theory. Englewood Cliffs;1967.
Chikalipo MC, Phiri LK, Mndolo N, et al. Perception of midwives towards magnesium sulfate use at Chatinkha Maternity Wing in Blantyre, Malawi: a qualitative study. Int J Womens Health 2020; 187–196.
Pakenham-Walsh N, Bukachi F. Information needs of health care workers in developing countries: a literature review with a focus on Africa. Hum Resour Health 2009; 7: 1–13.
Alhassan RK, Beyere CB, Nketiah-Amponsah E, et al. Perceived needs of health tutors in rural and urban health training institutions in Ghana: implications for health sector staff internal migration control. PLoS One 2017; 12: e0185748.
Palmer L, Newby BD. Development of a simplified protocol for administration of 20% magnesium sulphate for prophylaxis and treatment of eclampsia. Can J Hosp Pharm 2009; 62: 490.
Long Q, Oladapo OT, Leathersich S, et al. Clinical practice patterns on the use of magnesium sulphate for treatment of pre‐eclampsia and eclampsia: a multi‐country survey. BJOG An Int J Obstet Gynaecol 2017; 124: 1883–1890.
Pratt JJ, Niedle PS, Vogel JP, et al. Alternative regimens of magnesium sulfate for treatment of preeclampsia and eclampsia: a systematic review of non‐randomized studies. Acta Obstet Gynecol Scand 2016; 95: 144–156.
Vaishnav SB, Raithatha N, Kathawadia K, et al. Making Magnesium Sulfate Therapy Safer in Eclampsia: A Comparative Study of Zuspan Regime vs Low-dose Intravenous MgSO. J South Asian Fed Obstet Gynaecol 2019; 11: 127.
Lu JF, Nightingale CH. Magnesium sulfate in eclampsia and pre-eclampsia: pharmacokinetic principles. Clin Pharmacokinet 2000; 38: 305–314.
Chakraborty A, Can AS. Calcium gluconate. In: StatPearls [Internet]. StatPearls Publishing, 2022.
Cascella M, Vaqar S. Hypermagnesemia. StatPearls Publishing: Treasure Island, FL, USA, 2023.
Fondjo LA, Boamah VE, Fierti A, et al. Knowledge of preeclampsia and its associated factors among pregnant women: a possible link to reduce related adverse outcomes. BMC Pregnancy Childbirth 2019; 19: 1–7.
Sheikh S, Qureshi RN, Khowaja AR, et al. Health care provider knowledge and routine management of pre-eclampsia in Pakistan. Reprod Health 2016; 13: 107–113.
Olaoye T, Oyerinde OO, Elebuji OJ, et al. Knowledge, Perception and Management of Pre-eclampsia among Health Care Providers in a Maternity Hospital. Int J MCH AIDS 2019; 8: 80–88.
Barua A, Mundle S, Bracken H, et al. Facility and personnel factors influencing magnesium sulfate use for eclampsia and pre‐eclampsia in 3 Indian hospitals. Int J Gynecol Obstet 2011; 115: 231–234.
Jana N, Dasgupta S, Das AK, et al. Experience of a low-dose magnesium sulfate regimen for the management of eclampsia over a decade. Int J Gynecol Obstet 2013; 122: 13–17.
Oguntunde O, Charyeva Z, Cannon M, et al. Factors influencing the use of magnesium sulphate in pre-eclampsia/eclampsia management in health facilities in Northern Nigeria: a mixed methods study. BMC Pregnancy Childbirth 2015; 15: 1–8.
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Copyright (c) 2024 ABUBAKARI ABDULAI, Balkisu Seidu, Osman Adiza, Abdul-Malik Abdulai, Suraya Malle Mohammed, Fatimata Yakubu, Delilah Nonterah, Mohammed Mutawakil Ibrahim, Mohammed Abdulai Kojo, Mubarick Nungbaso Asumah
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